Oguamanam Okezie Enwere1 
,
Chinedu Valentine Eze2
For correspondence:- Oguamanam Enwere Email: okeyzie@yahoo.com Tel:+2348033260826
Received: 18 April 2013 Accepted: 30 January 2014 Published: 24 March 2014
Citation: Enwere OO, Eze CV. Reported Case of Paracetamol and Non-Steroidal Anti-Inflammatory Drug (NSAID)-Induced Seizures in a Patient with HIV Infection. Trop J Pharm Res 2014; 13(3):455-457 doi: 10.4314/tjpr.v13i3.21
© 2014 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Commonly available analgesics, such as paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs), are used widely with few or no adverse events by most individuals. However, some adverse events have been observed following the use of these drugs. This paper reports a case of paracetamol and NSAID-induced seizures in a patient with the human immunodeficiency virus infection/acquired immune deficiency syndrome (HIV/AIDS). These seizures occurred at different times, first with paracetamol and then diclofenac (a NSAID). She was concurrently on anti-retroviral drugs and antibiotics. We were unable to readily explain this unusual adverse event as most documented paracetamol-related adverse events are either immunoglobulin E (IgE)-mediated or due to direct paracetamol-induced hepatic necrosis following an overdose. This case is a probable drug-drug interaction not supported by existing literature, and it is possible that the background HIV infection may have a role to play.
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